N-acetyl-cysteine (NAC) is a form of the amino acid L-cysteine. It has long been used as a specific antidote for acetaminophen overdose and is also often used to treat various forms of cancer.
It is used in the presence of heavy metal poisoning for the treatment of infections and wounds. It is also used to treat HIV infection.
NAC is also important in the field of psychiatric medicine due to its effects on glutamate and dopamine in the brain.
In this context, the compound is used in the treatment of many serious neurological disorders, such as schizophrenia, Alzheimer's, addiction, depression and many other diseases. It is also an excellent antioxidant with strong neuro-protective properties.
N-acetyl-cysteine can be considered a “nootropic” part of the category of supplements, which consists of organic compounds that the body needs for metabolism, immunity and healthy cognitive function.
Effects of Acetyl Cysteine
All amino acids are protein structures in the body. They are needed for the growth of healthy tissues and the production of hormones that act as messengers for the communication of all brain systems.
In addition to this role, individual proteins can cause the secretion and balancing of specific neurochemicals. N-acetyl-cysteine regulates glutamate levels in the brain. It is a key compound involved in healthy metabolism and cellular energy.
NAC also mediates the amount of dopamine in the brain. Dopamine is a neurotransmitter associated with mental energy, driving, some motor control, pleasure, and mental attitudes.
Read more about dopamine. The role of dopamine in the brain - Mood, Attention, Goal Setting
The antioxidant effect of NAC occurs as the compounds are formed into glutathione, which is a natural precursor. Glutathione reduces the body's dangerous free radicals by donating electrons to them, and is itself stable.
Glutathione is the most valuable and strongest antioxidant in the whole body, it is a protein molecule of three amino acids (systeine, glycine and glutamic acid), as well as a deoxidizer, a booster of the immune system.
This action helps the cells fight bacteria, viruses, and is responsible for the benefits of NAC for poisoning or infectious diseases.
Acetyl Cysteine Benefits
N-acetyl-cysteine has many advantages and clinical applications. It can be used to cure and prevent alcohol damage to the liver. It actually has many antitoxic effects.
The interaction of NAC glutamate and dopamine can promote mental energy and attention control. For this reason, it is used in psychiatric practice in patients with low mental potential and / or difficulty controlling thoughts and concentration.
It is used in patients with ADHD, OCD, bipolar disorder, and schizophrenia. It has been used effectively to help quit smoking and help reduce other addictions.
The antioxidant value of the supplement is excellent for the prevention of heart and lung diseases, as well as the damage caused by overdose and poisoning by toxic metals.
Acetyl Cysteine Dosage
N-acetyl-cysteine has many dosing recommendations that correspond to many different uses.
In healthy adults, this supplement can be used as a general cognitive health supplement at a dose of up to 600 mg twice a day. This amount should improve focus and greater motivation.
Supplements such as NAC, can be considered as energy-stimulating stimulants, the same mental effect can be achieved by stimulating with cholinergic or racetam supplements. Supplements of this type increase acetylcholine, increasing cognitive power without a strong energy component.
More stimulating dopaminergic supplements, such as NAC, can be combined with choline-stimulating supplements to add a motivational component. Doses for special physical ailments, such as asthma, are usually lower, about 200 mg per day. Treatment for NAC infections or poisoning should only be performed by a physician.
Acetyl Cysteine Side Effects
N-acetyl-cysteine can cause severe gastrointestinal side effects in some people. These include vomiting, diarrhea, constipation and nausea. Some of these conditions are clearly related to toxicity when the supplement is used for treatment. Like all natural supplements, the best way to avoid side effects is to start taking lower doses.
NAC dilates blood vessels and can increase blood flow, so it should not be used with any blood clotting supplement or blood pressure medication. It should not be used in combination with strong stimulants that affect dopamine levels, such as Adderall. This combination can be overly stimulating and cause a fast heart rate and difficulty breathing. However, for most people, the side effects of NAC are mild and short-lived.
Acetyl Cysteine Review
The amino acid N-acetyl-cysteine has long been used as an antidote for toxic poisoning from tylenol or heavy metals. It has very strong antioxidant properties that are great for fighting serious infections, including HIV.
As a cognitive enhancement supplement, the ability of NAC to increase metabolism and increase dopamine levels results in better attention concentration and the benefits of higher energy levels. NAC is suitable for combination with known brain stimulators such as sources of choline.